Human Herpesvirus 8 in Italian HIV-Seronegative Patients With Kaposi Sarcoma

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Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru

To determine human herpesvirus 8 (HHV-8) K1 genotypes in patients with Kaposi sarcoma (KS) from Peru, we characterized HHV-8 in 25 KS biopsy samples. Our findings of 8 A, 1 B, 14 C, and 2 E subtypes showed high HHV-8 diversity in these patients and association between E genotype and KS development.

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Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a phylogenetically old human virus that co-evolved with human populations, but is now only common (seroprevalence greater than 10%) in sub-Saharan Africa, around the Mediterranean Sea, parts of South America and in a few ethnic communities. KSHV causes three human malignancies, Kaposi sarcoma, primary effusion lymp...

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ژورنال

عنوان ژورنال: Archives of Dermatology

سال: 1998

ISSN: 0003-987X

DOI: 10.1001/archderm.134.6.695